Planned engineering work will take place between Crewe and Manchester Piccadilly from 11.25pm today, Monday, to 5.20am on Friday.
All lines will be blocked while the work is expected to take place, with rail replacement busses covering services.
The delays come days after Minister for State Transport, Lord Hendy, told MPs that Christmas train services could be disrupted by staffing shortages.
A spokesperson from Northern said: “Some services will be replaced by buses throughout. The 00:44 (Tues,Thurs,Fri only) Crewe to Manchester Piccadilly service will be bus replaced throughout.
“This service WILL NOT RUN on Wednesday morning.
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“The 23:36 (Mon,Weds,Thurs only) Manchester Piccadilly to Crewe service will be bus replaced throughout. Note – this service WILL NOT RUN on Tuesday night.
“Normal journey times are extended by approximately 45 minutes. Please allow extra time for your journey.
“Please check station information posters or online for the location of the bus pick up points.
“For customers requiring mobility travel assistance please call us on 0800 138 5560 (Text Relay 18001 0800 138 5560).”
Further information about the changes, as well as rail replacement services can be found on Northern’s website.
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